Retatrutide

• Supports appetite control signals
• Encourages healthier body-composition shifts over time
• May support energy expenditure signaling
• Often studied for metabolic flexibility and glucose balance

Works like a three-in-one signal that talks to hunger, insulin, and energy-burn pathways. That multi-lane messaging can make appetite feel quieter while nudging the body to use fuel more efficiently.

Generally well tolerated. Minor side effects occasionally reported include: nausea, mild stomach upset, constipation or diarrhea, fatigue, and headache.

Appetite changes often show up earlier; body-composition changes usually take several weeks.

Often evaluated in multi-week blocks, with many people reassessing after 8-12 weeks before a break.

Have a question? Ask pep.ai